学术报告：Bioinformatics and Computational Approaches to the Structure analysis and Modeling of Membrane Proteins
报告题目：Bioinformatics and Computational Approaches to the Structure analysis and Modeling of Membrane Proteins报告人：Prof. Z. Li
Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, USA
报告时间 2010年7月12日 （周一） 上午 10:00
报告地点： 学术中心307房间
报告摘要：Membrane proteins account for approximately 30% of human genome and are important drug targets. Elucidating the three-dimensional structures of membrane proteins is crucial to understanding their structure-function relationships and to their structure-based drug design. In disparity to their biological and therapeutic importance, structures of membrane proteins represent less than 2% of the total structures in the Protein Data Bank. This is mainly due to the challenge of experimental structure determination of membrane proteins. As a result, computational modeling plays an important role in the studies of membrane proteins and in designing drugs targeting these proteins. In this talk, three ongoing projects from our lab that is related to structure analysis and modeling of helical membrane proteins will be presented: (1) Developing an objective measure for quality assessment of membrane protein structures or models; (2) Applying computational modeling techniques to the studies of chemoreceptors and their regulatory enzyme; and (3) Comparison analysis of primary ligand binding sites of seven-helix membrane proteins in an effort to understand the structural basis of their function specificity.
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