报告题目：Nanobiosensors and nano-bioimaging for Diagnostics and Therapeutics

报 告 人：Professor Ratnesh Lal, Depts. of Bioengineering, Materials Science, and Mechanical & Aerospace Engineering, and Co-Director, Center for Multiscale Imaging of Living Systems, IEM, UCSD

报告时间：2012年12月14日 上午 10:30

报告地点：嘉定园区学术活动中心307室

报告人简介：

　　

Prof. Lal received his MS/M Phil in Physics/Biophysics from JNU, India, Ph.D. in Neurobiology from UAB, and postdoctoral training at Caltech. He held faculty positions at the University of Chicago and UCSB and then the Director of the Center of Nanomedicine and professorships in Medicine, Biophysical Sciences and Cell Physiology at the University of Chicago. Currently, he holds joint professorships in Mechanical Engineering, Materials Science, and Bioengineering at UCSD. He was the UTS Invited Professor in Sydney for their Bionanotechnology initiative and a New Zealand Government International Science Scholar. He is an Associate Editor of the Journal Nanomedicine: Nanotechnology, Biology, Medicine, and is on advisory board of RC Nano LLC and Be Green Packaging LLC. He is a Fellow of AAAS (the American Association for Advancement of Science). He has presented many international keynote lectures and is featured in many popular magazines and news media, including Time, Smithsonian and UPI. He holds several patents based upon AFM cantilever arrays, microfluidics, optoelectronics and nanotubes for medical diagnostics, Nano biosensors and in-vivo medical Nano devices, nanoscale fluid behavior and new TIRF, FRET and related optical microscopy

报告简介：
　  Recent advances in nanoscience and technology have major impact on the merging field of Nanomedicine: a) understanding basic mechanisms of the disease, b) examining roles of cell and tissue interactions and environmental perturbations, both internal as well as external, c) the diagnoses of diseases using nanoscale sensors and devices, d) designing therapeutics and drugs, e) designing efficient delivery of drugs and therapeutics, and f) designing nano/micro-electrical & mechanical stimulations for maintaining various body activity. I will discuss how manipulating nanoscale structures, processes and intermolecular interactions could be used for biosensing and conceptualizing nanodevices for a wide array of diagnostics and therapeutics. The platform technology for these sensors and devices includes integrated cantilevered and optical scanning probe techniques including atomic force microscopy, nanofluidics, nanochips, NanoMEMS, nanoelectronics, and wireless technology. I will give examples of how imaging structures and dynamics of protein structures provide new paradigms of diseases as diverse as Alzheimer’s disease to smoking induced lung diseases. In the realm of nano-diagnostics, the greatest boon is the ability to build sensors for a variety of chemicals, chemical interactions, physical changes such as heat, electrical resistance, etc.　This when combined with the small device size would allow the use of chronically implanted, safe and long-lasting sensors.　Along with remote sensing and interrogation capabilities, this area has great potential in revolutionizing diagnoses of a variety of diseases. For example, we have envisioned a sensor for in-vivo edema detection and quantification and in-vitro rapid high-throughput test for allergens and an array of biomarkers for cancer and inflammatory diseases.