报告题目：Reading disc-based bioassays with standard computer optical drives

报 告 人：Hua-Zhong “Hogan” Yu

         Department of Chemistry and 4D Labs

         Department of Molecular Biology and Biochemistry

         Simon Fraser University, Vancouver, Canada

报告时间：2013年11月13日（星期三）上午10:30

报告地点：嘉定园区学术活动中心多功能厅

于化忠简介:

    于化忠博士现任加拿大温哥华市Simon Fraser University（SFU；西蒙弗雷泽大学）化学系教授，同时兼任4D先进材料实验中心专任研究员和分子生物学及生物化学系教授。于教授1991年毕业于济南山东大学化学系；1994年获山东大学和中科院大连化物所联合培养硕士学位（顾月姝教授和李学初研究员）；1997年获北京大学理学博士学位（刘忠范院士的首届博士研究生；北京大学优秀博士论文世顺奖）。同年赴美国加州理工学院(Caltech)开展博士后工作，师从诺贝尔奖获得者激光化学家兹维尔教授(Ahmed Zewail)和著名电化学家安森教授(Fred Anson)。2000年工作于加拿大国家科学院；2001年受聘于SFU，在2005 和2009年分别破格提前晋升为副教授和教授（生物分析化学和材料化学）。于化忠教授发表研究论文110篇，半数刊登在美国化学会(ACS)的核心期刊上；另有美国/国际专利4项。先后获加拿大化学会Fred Beamish 奖(2004)，日本学术振兴会访问教授奖(2008)，电化学会（美国）加拿大分会W. Lash Miller 奖 (2011)和国际电化学学会Tajima 奖(2012)。

报告简介：

Current guidelines for healthcare emphasize rapid testing and reporting, which can be better satisfied by near-patient or at-home point-of-care (POC) diagnosis rather than centralized medical laboratories using automated multi-analyte analyzers by trained professionals. With POC testing, the turn-around time will be significantly reduced, which ultimately leads to earlier decision making and more efficient medical treatment. At present, POC protocols are predominantly based on rapid-test immunoassay strips/cassettes, i.e., lateral-flow immunochromatographic assays that combine gold nanoparticles for colorimetric (mostly qualitative) detection and flow-through systems for sample delivery.

Compact disc (CD) technology is a promising alternative to today’s POC testing protocol, particularly in the development of a new generation diagnostic tools for on-site and at-home use. We have established both the surface chemistry and signal readout method for fabricating and running disc (CD-R, DVD)-based bioassays for various molecular analytes; these discAssays can be read quantitatively with standard computer optical drives and stand-alone disc players. Because no modification to either the hardware or the software driver is needed, this research promises a platform POC technology for rapid, low-cost, and high-throughput medical diagnosis.

References:

(1)Yu, H.-Z.; Li, Y.; Ou, L.M.L. Acc. Chem. Res. 2013, 46, 258–268.

(2)Li, Y.; Wang, Z.; Ou, L. M.-L.; Yu, H.-Z. Anal. Chem. 2007, 79, 426-433.

(3)Li, Y.; Ou, L. M.-L.; Yu, H.-Z. Anal. Chem. 2008, 80, 8216-8223.

(4)Wang, H.; Ou, L. M.-L.; Suo, Y.; Yu, H.-Z. Anal. Chem. 2011, 83, 1557-1563.