学术报告：Exploring Functional Nucleic Acids for Bioanalytical Applications
报告题目：Exploring Functional Nucleic Acids for Bioanalytical Applications
报 告 人：Yingfu Li（McMaster University）
报告时间：2014年10月28日（星期二）上午10:30
报告地点：嘉定园区学术活动中心多功能厅
ABSTRACT
Functional nucleic acids (FNAs) are single-stranded DNA or RNA sequences that are capable of carrying out ligand binding (aptamers and riboswitches), catalysis (ribozymes and DNAzymes) or both functions (aptazymes). FNAs have been recognized as valuable molecular tools in diverse fields including bioanalytical chemistry, chemical biology, nanotechnology and medical diagnostics and molecular medicine. In this presentation, I will discuss the efforts of my laboratory in the exploration of FNAs for various bioanalytical applications. Three classes of FNAs and relevant applications will be discussed: structure-switching aptamers that transduce molecular recognition events into fluorescent or colorimetric signals, fluorogenic DNAzymes that couple catalysis with fluorescent signal generation, and ribosensors that take advantage of naturally occurring riboswitches to regulate the expression of reporter genes such as beta-galactosidase, luciferase, and fluorescent proteins.
BIOGRAPHY
Yingfu Li was born and raised in Anhui, China. He received his BSc in chemistry at Anhui University in 1983, and his MSc in applied chemistry at Beijing Agriculture University in 1989, under the supervision of late Professor Changhai Zhou. He moved to Canada in 1992, and in 1997, he graduated with a PhD in chemistry and biochemistry at Simon Fraser University under the supervision of Professor Dipankar Sen. He then did his postdoctoral research with Professor Ronald Breaker at Yale University. In 1999, he joined McMaster University as an assistant professor in the Department of Biochemistry and Biomedical Sciences and the Department of Chemistry and Chemical Biology. He was promoted to the rank of associate professor in 2005 and full professor in 2010. His research interests include basic and applied research concerning catalytic DNAs (DNAzymes), DNA and RNA aptamers, riboswitches, non-coding RNAs and bacterial toxins.
报 告 人：Yingfu Li（McMaster University）
报告时间：2014年10月28日（星期二）上午10:30
报告地点：嘉定园区学术活动中心多功能厅
ABSTRACT
Functional nucleic acids (FNAs) are single-stranded DNA or RNA sequences that are capable of carrying out ligand binding (aptamers and riboswitches), catalysis (ribozymes and DNAzymes) or both functions (aptazymes). FNAs have been recognized as valuable molecular tools in diverse fields including bioanalytical chemistry, chemical biology, nanotechnology and medical diagnostics and molecular medicine. In this presentation, I will discuss the efforts of my laboratory in the exploration of FNAs for various bioanalytical applications. Three classes of FNAs and relevant applications will be discussed: structure-switching aptamers that transduce molecular recognition events into fluorescent or colorimetric signals, fluorogenic DNAzymes that couple catalysis with fluorescent signal generation, and ribosensors that take advantage of naturally occurring riboswitches to regulate the expression of reporter genes such as beta-galactosidase, luciferase, and fluorescent proteins.
BIOGRAPHY
Yingfu Li was born and raised in Anhui, China. He received his BSc in chemistry at Anhui University in 1983, and his MSc in applied chemistry at Beijing Agriculture University in 1989, under the supervision of late Professor Changhai Zhou. He moved to Canada in 1992, and in 1997, he graduated with a PhD in chemistry and biochemistry at Simon Fraser University under the supervision of Professor Dipankar Sen. He then did his postdoctoral research with Professor Ronald Breaker at Yale University. In 1999, he joined McMaster University as an assistant professor in the Department of Biochemistry and Biomedical Sciences and the Department of Chemistry and Chemical Biology. He was promoted to the rank of associate professor in 2005 and full professor in 2010. His research interests include basic and applied research concerning catalytic DNAs (DNAzymes), DNA and RNA aptamers, riboswitches, non-coding RNAs and bacterial toxins.
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