学术报告:Biologically Inspired Engineering of Self-assembling and Multi-functional Underwater Adhesives

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报告题目:Biologically Inspired Engineering of Self-assembling and Multi-functional Underwater Adhesives 
报 告 人:Chao Zhong, Assistant Professor (Tenure-track),上海科技大学物质学院 
报告时间:2014年11月25日(周二),下午2:15 
报告地点:嘉定学术活动中心302室 

报告人简介: 
    钟超博士于天津大学获得材料科学本科,在美国康奈尔大学获得生物医学工程博士,他曾先后在美国华盛顿大学(西雅图分校)材料系、麻省理工学院电子工程和计算机科学系,生物工程系从事博士后工作。2014年7月,他加入新成立的上海科技大学,成立生物灵感分子工程实验室。他的研究兴趣包括生物灵感材料,生物纳米技术以及合成生物学在以上领域的应用。他是生物医学工程学会(BMES),材料研究学会(MRS),美国化学学会(ACS)和生物材料学会(SFB)的会员。他已发表了18篇学术论文,包括发表在自然纳米技术,自然通信和先进材料等杂志内的一作论文。 

Abstract:   
  Many natural underwater adhesives harness hierarchically assembled amyloid nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent environments. Despite recent advances, our understanding of the molecular design, self-assembly and structure–function relationships of these natural amyloid fibres remains limited. Thus, designing biomimetic amyloid-based adhesives remains challenging. Here, we report strong and multi-functional underwater adhesives obtained from fusing mussel foot proteins (Mfps) of Mytilus galloprovincialis with CsgA proteins, the major subunit of Escherichia coli amyloid curli fibres. These hybrid molecular materials hierarchically self-assemble into higher-order structures, in which, according to molecular dynamics simulations, disordered adhesive Mfp domains are exposed on the exterior of amyloid cores formed by CsgA. Our fibres have an underwater adhesion energy approaching20.9 mJ m−2, which is 1.5 times greater than the maximum of bio-inspired and bio-derived protein-based underwater adhesives reported thus far. Moreover, they outperform Mfps or curli fibres taken on their own and exhibit better tolerance to auto-oxidation than Mfps at pH ≥7.0.
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