学术报告：Non-viral gene therapy mediated by cationic helical polypeptides
报告题目：Non-viral gene therapy mediated by cationic helical polypeptides
报 告 人：殷黎晨（苏州大学）
报告时间：2014年12月11日（星期四）上午10：30
报告地点：嘉定园区学术活动中心307室
报告人简介：
2010年毕业于复旦大学生命科学学院，获生物化学与分子生物学专业博士学位。2010.11月至2014.1月在美国伊利诺伊大学香槟分校从事博士后研究工作。2014年1月加盟苏州大学功能纳米与软物质研究院，被聘为教授、博士生导师。主要从事蛋白质、核酸等生物大分子药物给药系统研究如水溶性多肽、聚酯、多糖及其纳米载体的开发并研究其在基因治疗中的应用。2007年以来在Angew Chem Int Ed，Adv Mater，JACS，Chem Sci，Biomaterials，J Control Release等生物材料知名期刊上发表学术论文40余篇，多篇论文被包括C&EN News，Materials View China，Fierce Drug Delivery，Illinois News在内的媒体作为亮点报道。获中国专利3项，美国专利1项。
报告简介：
Non-viral gene therapy provides a promising tool for the treatment of human diseases, but its clinical application is largely hurdled by the lack of efficient delivery vectors. We recently developed a bioactive and reactive template for the preparation of a library of cationic α-helical polypeptides; upon structural reconfiguration and functionalization, these helical polypeptides were endowed with unprecedented membrane activities and gene delivery capabilities, which can outperform commercial reagents by 1-2 orders of magnitude. This novel technology thus provides an important addition to the existing gene delivery systems, and will address several critical challenges in the field of non-viral gene delivery.
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