学术报告：Structure and function characterization of DNA-SWCNT hybrid
报告题目：Structure and function characterization of DNA-SWCNT hybrid
报 告 人：郑明（National Institute of Standards and Technology）
-Peking University, BS (1984) and MS (1987) in Electronics
-University of Utah, MS in Physics, 1990
-Princeton University, Ph.D. in Chemistry (with Professor Charles Dismukes), 1995
National Institute of Child Health and Human Development (1996-2000);
DuPont Central Research and Development (2000-2009) Principal Investigator ;
National Institute of Standards and Technology (2009-present)，Materials Science and Engineering Division , Research Chemist (2009-present) .
His research area is at the interface of materials and biochemical sciences. They explore interactions between inorganic nanostructures and biomolecules. They exploit such interactions to create new hybrid structures and functions on one hand, and to discover new biomolecular folding patterns on the other.
Their earlier work has led to the finding of a family of molecular structures: DNA- single wall carbon nanotube (SWCNT) hybrid (see figure below). SWCNTs are one-dimensional molecules that have the same cylindrical shape but different chiralities. Many fundamental studies and technological applications of SWCNT require a population of tubes with identical chirality that current syntheses can not provide. By constructing DNA-SWCNT hybrids with specific ssDNA sequences, they are able to chromatographically separate SWCNTs by their chiralities. SWCNT also provides a unique platform to study nucleic acid folding and other biophysical properties. Potential application of DNA/SWCNT interactions ranges from biosensing to DNA sequencing.
His current research covers the following two related areas:
1. Structure and function characterization of DNA-SWCNT hybrid, mechanistic understanding of the DNA-based SWCNT sorting method and its further development.
2. Engineering DNA-SWCNT hybrid as a measurement tool for biological applications.
In addition, we also provide purified materials to collaborators both outside and inside NIST to enable their fundamental measurements on SWCNTs.
American Cancer Society Postdoctoral Fellow, 1997 – 2000
Chemical Research Council Collaborative Award, 2006
“Nano 50” Inventors Award, 2007
1 Tu, X., Manohar, S., Jagota, A. & Zheng, M. DNA sequence motifs for structure-specific recognition and separation of carbon nanotubes. Nature 460, 250-253 (2009).
2 Tu, X. & Zheng, M. A DNA-based Approach to the Carbon Nanotube Sorting Problem. Nano Research 1, 185-194 (2008).
3 Zheng, M. & Semke, E. D. Enrichment of Single Chirality Carbon Nanotubes. J Am Chem Soc. 129, 6084-6085 (2007).
4 Mclean, R. S., Huang, X., Khripin, C., Jagota, A. & Zheng, M. Controlled two-dimensional pattern of spontaneously aligned carbon nanotubes. Nano Lett. 6, 55-60 (2006).
5 Huang, X., Mclean, R. S. & Zheng, M. High-resolution length sorting and purification of DNA-wrapped carbon nanotubes by size-exclusion chromatography. Anal. Chem. 77, 6225-6228 (2005).
6 Zheng, M. & Diner, B. A. Solution redox chemistry of carbon nanotubes. J Am Chem Soc. 126, 15490-15494 (2004).
7 Zheng, M. et al. DNA-assisted dispersion and separation of carbon nanotubes. Nat Mater. 2, 338-342 (2003).
8 Zheng, M. et al. Structure-based carbon nanotube sorting by sequence-dependent DNA assembly. Science 302, 1545-1548 (2003).