报告题目：Biophysical Analyses of Immune Regulation

报 告 人：石彦 教授，清华大学医学院

报告时间：2015年10月30日（周五）下午15:00

报告地点：嘉定园区学术活动307房间

报告简介：

Historically, immunological research has been a protein-centric endeavor, with signaling events often defined as biochemical changes of polypeptides. How biophysical factors play into this scheme has been mostly overlooked. We used atomic force microscopy (AFM)-based single cell force spectroscopy (SCFS) to elucidate several important immunological events that are driven by biophysical changes at the cell membrane. We have found that particulate substances ligate surface lipid moieties with substantial intensity, causing rearrangement of the bilayer membrane. This lipid sorting aggregates signaling molecules and triggers phagocytosis and dendritic cell activation. Our work therefore introduces the concept of force and physical disturbance into the realm of immune activation. Recently we have moved this concept forward and suggest that the immune system is constantly under the regulation of biophysical factors. In particular we provide evidence that regulatory T cells, a group of CD4+ T cells essential to control autoimmunity, bind strongly to dendritic cells and suppress the latter’s ability to mount unwanted immune activation.　This line of research opens a new page in immunological understanding, and introduces biophysics as an essential aspect of immune regulation.

报告人简介：

1982/09-1988/06 上海医科大学公共卫生学士

1988/09-1991/01 上海检疫所医师

1991/01-1992/12 美国衣阿华大学预防医学硕士

1992/12-1998/06 美国衣阿华大学免疫学博士

1998/06-2006/03 美国马萨诸塞大学博士后及助教授

2006/03-2010/03 加拿大卡尔加里大学助理教授

2010/03-2012/03 加拿大卡尔加里大学副教授

2012/03-至今 清华大学教授

代表性论文：

Disruption of key GTPase regulators of endocytic recycling compartment does not interfere with soluble antigen crosspresentation in dendritic cells Cell Mol Immunol 2015

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact Sci Rep 2014

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection Nat Med 2013

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion J Clin Invest 2013

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity Nat Med 2011

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A. 2011

Important Roles of PIP5K1C in Neutrophil Recruitment Immunity 2010

Caught red-handed: uric acid is an agent of inflammation　Journal of Clinical Investigation2010

Monosodium urate crystals in inflammation and immunity　Immunological Reviews 2010

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells Immunity 2007

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci U S A 2000

Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003